(from Manual of Clinical Oncology)
Early lesions are commonly T1 and T2 with negative nodes; advanced lesions are T3 and T4, or any tumor with positive regional lymph nodes.
KEY
R = radiation therapy
S = Surgery
C = Chemotherapy
/ = a choice of treatments (preferred modality is first)
( ) = a lesser therapeutic alternative
| Primary | Early | Advanced |
| Lip | R/S | S/R |
| Oral Cavity | ||
| Oral tongue | S/R | S+R |
| Floor of mouth | S/R | S+R |
| Gingiva | S | S+R |
| Hard Palate | S | S+R |
| Buccal mucosa | S/R | S+R |
| Retromolar trigone | S | S+R |
| Oropharynx | ||
| Soft palate | R | R/chmo+S |
| Tonsillar fossa | S/R | S+R |
| Anterior tonsillar pillar | S/R | S+R |
| Pharyngeal tongue | S/R | R/chmo+S |
| Pharyngeal wall | R | S+R |
| Hypopharynx | ||
| Pyriform sinus | S/R/C | R or S/R/C |
| Posterior pharynx | R/C | R/S/C |
| Larynx | ||
| Glottic (vocal cord) | R/(S) | S+R/C |
| Supraglottic | R/(S) | S+R/C |
| Subglottic | S/R | S+R/C |
| Nasopharynx | R/C | R/C |
| Paranasal sinuses | ||
| Nasal cavity | S/R/C | S+R |
| Nasal vestibule | R/(S)/C | R |
| Ethmoid sinus | S+R/C | S+R |
| Frontal and sphenoid sinuses |
R/S/C | R |
| Maxillary antrum | S/R/C | S+R±C |
| Salivary glands | ||
| Parotid gland | S±R | S±R |
| Submandibular gland | S, S+R | S+R |
| Thyroid gland | S | S+R (ablation) |