Perhaps the most important change between ICD-O-2 and ICD-O-3
involves a small number of disease entities that have changed
behavior codes.
Terms Changing from Borderline to Malignant Behavior
Eleven diagnoses are changing from
borderline to malignant to reflect current medical understanding
about the behavior of these neoplasms. They include all of
the refractory anemia types, polycythemia vera, a number of
other hematopoietic diseases, and papillary meningioma,. The
change from behavior code 1 (borderline) to behavior code
3 (malignant) will make these diseases reportable to cancer
registries that do not currently require their collection.
The impact on cancer registries that must add these cases
to their databases is not believed to be substantial. SEER
estimates 5,000 to 10,000 new cases per year in the U.S.,
about the frequency of pharynx, gallbladder, or testicular
cancer or Hodgkin's disease or chronic lymphocytic leukemia.
It will, however, be necessary to add new codes to current
casefinding code lists in order to identify these newly reportable
diagnoses from the medical record disease indices.
Terms that Changed to Malignant Behavior
ICD-O-2
Code
|
Primary
term as it appeared in ICD-O-2 |
ICD-O-3
Code |
| 8931/1 |
Endolymphatic
stromal myosis (C54.1) |
8931/3 |
| 9134/1 |
Intravascular
bronchial alveolar tumor (C34._) |
9133/3 |
| 9393/1 |
Papillary
ependymoma |
9393/3 |
| 9538/1
|
Papillary
meningioma |
9538/3 |
| 9950/1
|
Polycythemia
vera |
9950/3 |
| 9960/1 |
Chronic
myeloproliferative disease, NOS |
9960/3 |
| 9961/1 |
Myelosclerosis
with myeloid metaplasia |
9961/3 |
| 9962/1 |
Idiopathic
thrombocythemia |
9962/3 |
| 9980/1 |
Refractory
anemia, NOS |
9980/3 |
| 9981/1 |
Refractory
anemia without sideroblasts |
9980/3 |
| 9982/1
|
Refractory
anemia with sideroblasts |
9982/3 |
| 9983/1 |
Refractory
anemia with excess blasts |
9983/3 |
| 9984/1 |
Refractory
anemia with excess blasts in transformation |
9984/3 |
| 9989/1 |
Myelodysplastic
syndrome, NOS |
9989/3 |
|
Terms Changing from Malignant to Borderline Behavior
Five neoplasms previously coded as malignant (/3) will revert
to borderline status: the cystadenomas of the ovary. A careful
review of survival rates for the cystadenomas, which had been
considered malignant while ICD-O-2 was in effect, indicated
that their behavior was much closer to benign rather than
malignant and the overall survival rate for them was nearly
100%. In most registries, these neoplasms will now be considered
non-reportable and it will not be necessary to collect them.
Cystadenomas of the ovary collected during the period when
ICD-O-2 was in effect may be deleted from registry databases
at the discretion of the database manager or standard-setting
agency. One additional term, pilocytic or juvenile astrocytoma,
and one obsolete term (spongioblastoma, NOS) will also revert
to borderline behavior. However, for the sake of continuity,
pilocytic astrocytoma will continue to be collected in many
registries for the next few years.
Terms that Changed from Malignant to Borderline
| ICD-O-2
Code |
Primary
term as it appears in ICD-O-3 |
ICD-O-3
Code
|
| 8442/3 |
Serous
cystadenoma, borderline malignancy (C56.9) |
8442/1 |
| 8451/3 |
Papillary
cystadenoma, borderline malignancy (C56.9) |
8451/1 |
| 8462/3 |
Serous
papillary cystic tumor of borderline malignancy
(C56.9) |
8462/1 |
| 8472/3
|
Mucinous
cystic tumor of borderline malignancy (C56.9) |
8472/1 |
| 8473/3
|
Papillary
mucinous cystadenoma, borderline malignancy
(C56.9) |
8473/1 |
| 9421/3 |
Pilocytic
astrocytoma (C71._) |
9421/1 |
| 9422/3 |
Spongioblastoma,
NOS (C71._) |
9421/1 |
|
There are also other tumors that have changed to or from
borderline status; these diagnoses are considered non-reportable
by most cancer registries.
Terms that Changed from Benign to Borderline
Behavior
| ICD-O-2
Code |
Primary
term as it appears in ICD-O-3 |
ICD-O-3 Code |
| 8120/0 |
Transitional
cell papilloma, NOS |
8120/1 |
| 8152/0 |
Glucagonoma,
NOS (C25._) |
8152/1 |
| 8580/0 |
Thymoma,
NOS (C37.9) |
8580/1 |
| 8640/0 |
Sertoli
cell tumor, NOS |
8640/1 |
| 9506/0 |
Neurocytoma |
9506/1 |
|
Terms that Changed from Borderline to Benign Behavior
| ICD-O-2
Code |
Primary
term as it appears in ICD-O-3 |
ICD-O-3
Code |
| 8261/1 |
Villous
adenoma, NOS |
8261/0 |
| 8361/1 |
Juxtaglomerular
tumor (C64.9) |
8361/0 |
| 8823/1 |
Desmoplastic
fibroma |
8823/0 |
| 9080/1 |
Mature
teratoma |
9080/0 |
|
|
